Article
Genetic variants in the NF-κB signaling pathway (NFKB1, NFKBIA, NFKBIZ) and risk of critical outcome among COVID-19 patients.
Human immunology - 1 Jan 2000
Camblor Daniel G, Miranda Daniel, Albaiceta Guillermo M, Amado-Rodríguez Laura, Cuesta-Llavona Elías, Vázquez-Coto Daniel, Gómez de Oña Julia, García-Lago Claudia, Gómez Juan, Coto Eliecer
Abstract excerpt
The NF-κB signaling pathway is a key regulator of inflammation in the response to SARS-CoV-2 infection. This pathway has been implicated in the hyperinflammatory state that characterizes the severe forms of COVID-19. The genetic variation of the NF-κB components might thus explain the predisposition to critical outcomes of this viral disease. We aimed to study the role of the common NFKB1 rs28362491, NFKBIA rs696...
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