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Article

The natural killer cell-associated rs9916629-C allele is a novel genetic risk factor for fatal COVID-19.

Journal of medical virology - 1 Jan 2023

Vietzen Hannes, Furlano Philippe L, Traugott Marianna, Totschnig David, Hoepler Wolfgang, Strassl Robert, Zoufaly Alexander, Puchhammer-Stöckl Elisabeth

Abstract excerpt

The severity of COVID-19 is associated with individual genetic host factors. Among these, genetic polymorphisms affecting natural killer (NK) cell responses, as variations in the HLA-E- (HLA-E*0101/0103), FcγRIIIa- (FcγRIIIa-158-F/V), and NKG2C- (KLRC2wt/del ) receptor, were associated with severe COVID-19. Recently, the rs9916629-C/T genetic polymorphism was identified that indirectly shape the human NK cell...

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Identifiers

PMID: 36515427
DOI: 10.1002/jmv.28404
PMCID: PMC9878105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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