Article
The natural killer cell-associated rs9916629-C allele is a novel genetic risk factor for fatal COVID-19.
Journal of medical virology - 1 Jan 2023
Vietzen Hannes, Furlano Philippe L, Traugott Marianna, Totschnig David, Hoepler Wolfgang, Strassl Robert, Zoufaly Alexander, Puchhammer-Stöckl Elisabeth
Abstract excerpt
The severity of COVID-19 is associated with individual genetic host factors. Among these, genetic polymorphisms affecting natural killer (NK) cell responses, as variations in the HLA-E- (HLA-E*0101/0103), FcγRIIIa- (FcγRIIIa-158-F/V), and NKG2C- (KLRC2wt/del ) receptor, were associated with sever...
Topics
- Aged
- Humans
- Alleles
- COVID-19
- Killer Cells, Natural
- NK Cell Lectin-Like Receptor Subfamily C
- Polymorphism, Genetic
- Risk Factors