Diagnostic and prognostic significance of IL-18 and its -607C/A polymorphism in COVID-19: Implications for CURB-65 severity scoring.

doi:10.1016/j.ric.2026.100034

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Article

Diagnostic and prognostic significance of IL-18 and its -607C/A polymorphism in COVID-19: Implications for CURB-65 severity scoring.

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion - 1 Jan 2026

Rafeeq Dawan Dlshad, Othman Baghawan Ahmed, Kakoo Ashraf, Smail Shukur Wasman, Yashooa Raya Kh, Ghareeb Asmaa Ameen, Salih Rebaz Hamza, Janson Christer

Abstract excerpt

BACKGROUND: Interleukin-18 (IL-18) is a key inflammasome-related cytokine implicated in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. OBJECTIVE: This study investigated the diagnostic, prognostic, and immunogenetic relevance of IL-18 and its promoter polymorphism (-607C/...

Topics

Humans
Interleukin-18
COVID-19
Severity of Illness Index
Prognosis
Middle Aged
Female
Male
Case-Control Studies
Adult
Aged
Genetic Predisposition to Disease
Promoter Regions, Genetic
Genotype

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Open in PubMed

Identifiers

PMID: 41610796
DOI: 10.1016/j.ric.2026.100034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-41610796-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Polymorphism, Single Nucleotide