Article
The TNFRSF13C H159Y Variant Is Associated with Severe COVID-19: A Retrospective Study of 500 Patients from Southern Italy.
Genes - 8 Jun 2021
Russo Roberta, Andolfo Immacolata, Lasorsa Vito Alessandro, Cantalupo Sueva, Marra Roberta, Frisso Giulia, Abete Pasquale, Cassese Gian Marco, Servillo Giuseppe, Esposito Gabriella, Gentile Ivan, Piscopo Carmelo, Della Monica Matteo, Fiorentino Giuseppe, Russo Giuseppe, Cerino Pellegrino, Buonerba Carlo, Pierri Biancamaria, Zollo Massimo, Iolascon Achille, Capasso Mario
Abstract excerpt
To identify host genetic determinants involved in humoral immunity and associated with the risk of developing severe COVID-19, we analyzed 500 SARS-CoV-2 positive subjects from Southern Italy. We examined the coding sequences of 10 common variable immunodeficiency-associated genes obtained by the whole-exome sequencing of 121 hospitalized patients. These 10 genes showed significant enrichment in predicted...
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