Article
Association of IL-10-592 C > A /-1082 A > G and the TNFα -308 G > A with susceptibility to COVID-19 and clinical outcomes.
BMC medical genomics - 29 Jan 2024
Eldesouki Raghda E, Kishk Rania M, Abd El-Fadeal Noha M, Mahran Rama I, Kamel Noha, Riad Eman, Nemr Nader, Kishk Safaa M, Mohammed Eman Abdel-Moemen
Abstract excerpt
BACKGROUND: Variation in host immune responses to SARS-CoV-2 is regulated by multiple genes involved in innate viral response and cytokine storm emergence like IL-10 and TNFa gene polymorphisms. We hypothesize that IL-10; -592 C > A and - 1082 A > G and TNFa-308 G > A are associated with the risk...
Topics
- Humans
- COVID-19
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Interleukin-10
- Polymorphism, Single Nucleotide
- RNA, Viral
- SARS-CoV-2
- Tumor Necrosis Factor-alpha