Article
Inflammasome genes polymorphisms are associated with progression to mechanical ventilation and death in a cohort of hospitalized COVID-19 patients in a reference hospital in Rio de Janeiro, Brazil.
Gene - 20 May 2023
Neira-Goulart Milena, de Sá Nathalia Beatriz Ramos, Ribeiro-Alves Marcelo, Perazzo Hugo, Geraldo Kim Mattos, Ribeiro Maria Pia Diniz, Cardoso Sandra Wagner, Grinsztejn Beatriz, Veloso Valdiléa G, Rodrigues Gomes Larissa, Cazote Andressa da Silva, de Almeida Dalziza Victalina, Giacoia-Gripp Carmem Beatriz Wagner, Côrtes Fernanda Heloise, Morgado Mariza Gonçalves
Abstract excerpt
COVID-19 has a broad spectrum of clinical manifestations. We assessed the impact of single nucleotide polymorphisms (SNPs) of inflammasome genesas risk factors for progression toCOVID-19 critical outcomes, such as mechanical ventilation support (MVS) or death.The study included 451 hospitalized individuals followed up at the INI/FIOCRUZ, Rio de Janeiro, Brazil, from 06/2020 to 03/2021. SNPs genotyping was...
Topics
- Humans
- Brazil
- CARD Signaling Adaptor Proteins
- COVID-19
- Genetic Predisposition to Disease
- Genotype
- Inflammasomes
- Neoplasm Proteins