Association of the IL6 rs1800795 polymorphism with COVID-19 clinical severity in a Brazilian population.

doi:10.1016/j.humimm.2026.111773

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Article

Association of the IL6 rs1800795 polymorphism with COVID-19 clinical severity in a Brazilian population.

Human immunology - 1 Aug 2026

Rocha Gabriela Dias, Silva Ana Tércia Paulo, Armstrong Anderson da Costa, Souza Carlos Dornels Freire, Carmo Rodrigo Feliciano

Abstract excerpt

A dysregulated inflammatory response is a central mechanism underlying severe COVID-19, with elevated serum IL-6 and TNF-α levels consistently associated with increased disease severity and mortality. Growing evidence indicates that host genetic factors influence individual susceptibility to adve...

Topics

Humans
Interleukin-6
Brazil
Female
COVID-19
Male
Polymorphism, Single Nucleotide
SARS-CoV-2
Tumor Necrosis Factor-alpha
Middle Aged
Severity of Illness Index
Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Cross-Sectional Studies

Adult

Genotype

Aged

Pandemics

Source

Open in PubMed

Identifiers

PMID: 42251847
DOI: 10.1016/j.humimm.2026.111773

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-42251847-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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