Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of the IL6 rs1800795 polymorphism with COVID-19 clinical severity in a Brazilian population.

Human immunology - 1 Aug 2026

Rocha Gabriela Dias, Silva Ana Tércia Paulo, Armstrong Anderson da Costa, Souza Carlos Dornels Freire, Carmo Rodrigo Feliciano

Abstract excerpt

A dysregulated inflammatory response is a central mechanism underlying severe COVID-19, with elevated serum IL-6 and TNF-α levels consistently associated with increased disease severity and mortality. Growing evidence indicates that host genetic factors influence individual susceptibility to adverse outcomes. We investigated the association of the rs1800795 (IL6) and rs1800629 (TNF) polymorphisms with COVID-19...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Aged
Share to Cross-Sectional Studies
Share to Gene Frequency
Share to TNF gene
Share to Genetic Predisposition to Disease
Share to Genotype
Share to Polymorphism, Single Nucleotide
Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 42251847
DOI: 10.1016/j.humimm.2026.111773

Genes

IL6
TNF
GC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of the IL6 rs1800795 polymorphism with COVID-19 clinical severity in a Brazilian population.PMID 42251847Read ↗

Impact of IL-6 rs1800795 and IL-17A rs2275913 gene polymorphisms on the COVID-19 prognosis and susceptibility in a sample of Iranian patients.Semantic proximity Read ↗

Impact of IL-6 rs1800795 and rs1800796 polymorphisms on clinical outcomes of COVID-19: a study on severity of disease in Turkish population.Semantic proximity Read ↗

Association of pro-inflammatory and anti-inflammatory cytokine polymorphisms with COVID-19 severity in unvaccinated patientsSemantic proximity Read ↗

The Interleukin-6 gene variants may protect against SARS-CoV-2 infection and the severity of COVID-19: a case-control study in a Moroccan population.Semantic proximity Read ↗

Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population.Semantic proximity Read ↗

High nasopharyngeal and serum IL-6 levels and the − 573G > C polymorphism (rs1800796) are linked with the risk of severe COVID-19 in a Mexican population: a case‒control studySemantic proximity Read ↗

Association of Interleukin-6 (rs1800795) and Interleukin-10 (rs1800896) Genetic Polymorphisms with the Outcome of COVID-19 Infection: A Single Center Study.Semantic proximity Read ↗

Association of polymorphisms of IL-6 pathway genes ( <i>IL6, IL6R</i> and <i>IL6ST</i> ) with COVID-19 severity in an Amazonian populationSemantic proximity Read ↗

Single nucleotide polymorphisms located in TNFA, IL1RN, IL6R, and IL6 genes are associated with COVID-19 risk and severity in an Iranian population.Semantic proximity Read ↗

Influence of IL-6 rs1800795 and IL-8 rs2227306 polymorphisms on COVID-19 outcome.Semantic proximity Read ↗

Interleukin-1 Beta rs16944 and rs1143634 and Interleukin-6 Receptor rs12083537 Single Nucleotide Polymorphisms as Potential Predictors of COVID-19 Severity.Semantic proximity Read ↗

Impact of IL-6 rs1800795 and IL-17A rs2275913 Gene Polymorphisms on the COVID-19 Prognosis and Susceptibility in a Sample of Iranian PatientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.