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Article

Cas9/Nickase-induced allelic conversion by homologous chromosome-templated repair in Drosophila somatic cells.

Science advances - 1 Jul 2022

Roy Sitara, Juste Sara Sanz, Sneider Marketta, Auradkar Ankush, Klanseck Carissa, Li Zhiqian, Julio Alison Henrique Ferreira, Lopez del Amo Victor, Bier Ethan, Guichard Annabel

Abstract excerpt

Repair of double-strand breaks (DSBs) in somatic cells is primarily accomplished by error-prone nonhomologous end joining and less frequently by precise homology-directed repair preferentially using the sister chromatid as a template. Here, a Drosophila system performs efficient somatic repair of both DSBs and single-strand breaks (SSBs) using intact sequences from the homologous chromosome in a process we refer...

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Identifiers

PMID: 35776792
DOI: 10.1126/sciadv.abo0721
PMCID: PMC10883370

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