Article

CD301b lectin expression in the breast tumor microenvironment augments tumor growth

2024-03-15

Abstract excerpt

Aberrant tumor glycosylation can alter immune recognition; however, the specific influence of glycan-lectin interactions on tumor progression remains poorly understood. Here, we identify the C-type lectin receptor CD301b (encoded by Mgl2 ) as a regulator of immune activity within the breast tumor microenvironment (TME). Using a murine triple-negative breast cancer model, we demonstrate that tumors expressing the...

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Literature Corpus work: 0bd45362-2b55-56db-bfdb-352c1ef47e1f
DOI: 10.1101/2024.03.13.584829

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