Article

<i>In Vivo</i> CRISPR Screens Identify E3 Ligase Cop1 as a Modulator of Macrophage Infiltration and Cancer Immunotherapy Target

2020-12-10

Abstract excerpt

<h4>SUMMARY</h4> Despite remarkable clinical efficacies of immune checkpoint blockade (ICB) in cancer treatment, ICB benefits in triple-negative breast cancer (TNBC) remain limited. Through pooled in vivo CRISPR knockout (KO) screens in syngeneic TNBC mouse models, we found that inhibition of the E3 ubiquitin ligase Cop1 in cancer cells decreases the secretion of macrophage-associated chemokines, reduces tumor...

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Literature Corpus work: e4a63a57-3ccd-53ad-a4b1-c7af14f1aeba
DOI: 10.1101/2020.12.09.418012

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