Article
B Cells and T Follicular Helper Cells Mediate Response to Checkpoint Inhibitors in High Mutation Burden Mouse Models of Breast Cancer.
Cell - 14 Nov 2019
Hollern Daniel P, Xu Nuo, Thennavan Aatish, Glodowski Cherise, Garcia-Recio Susana, Mott Kevin R, He Xiaping, Garay Joseph P, Carey-Ewend Kelly, Marron David, Ford John, Liu Siyao, Vick Sarah C, Martin Miguel, Parker Joel S, Vincent Benjamin G, Serody Jonathan S, Perou Charles M
Abstract excerpt
This study identifies mechanisms mediating responses to immune checkpoint inhibitors using mouse models of triple-negative breast cancer. By creating new mammary tumor models, we find that tumor mutation burden and specific immune cells are associated with response. Further, we developed a rich resource of single-cell RNA-seq and bulk mRNA-seq data of immunotherapy-treated and non-treated tumors from sensitive...
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