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Article

Antigenic Site Immunodominance Redirection Following Repeat Variant Exposure.

Viruses - 14 Jun 2022

Lindesmith Lisa C, Brewer-Jensen Paul D, Mallory Michael L, Zweigart Mark R, May Samantha R, Kelly Daniel, Williams Rachel, Becker-Dreps Sylvia, Bucardo Filemón, Allen David J, Breuer Judith, Baric Ralph S

Abstract excerpt

Human norovirus is a leading cause of acute gastroenteritis, driven by antigenic variants within the GII.4 genotype. Antibody responses to GII.4 vaccination in adults are shaped by immune memory. How children without extensive immune memory will respond to GII.4 vaccination has not been reported. Here, we characterized the GII.4 neutralizing antibody (nAb) landscape following natural infection using a surrogate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35746763
DOI: 10.3390/v14061293
PMCID: PMC9229260

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