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Emergence of a Norovirus GII.4 Strain Correlates with Changes in Evolving Blockade Epitopes

27 Dec 2012

Abstract excerpt

The major capsid protein of norovirus GII.4 strains is evolving rapidly, resulting in epidemic strains with altered antigenicity. GII.4.2006 Minerva strains circulated at pandemic levels in 2006 and persisted at lower levels until 2009. In 2009, a new GII.4 variant, GII.4.2009 New Orleans, emerged and since then has become the predominant strain circulating in human populations. To determine whether changes in...

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PMID: 23269783
DOI: 10.1128/jvi.03106-12

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