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Article

Antigenic Relatedness of Norovirus GII.4 Variants Determined by Human Challenge Sera.

PloS one - 1 Jan 2015

Dai Ying-Chun, Zhang Xu-Fu, Xia Ming, Tan Ming, Quigley Christina, Lei Wen, Fang Hao, Zhong Weiming, Lee Bonita, Pang Xiaoli, Nie Jun, Jiang Xi

Abstract excerpt

The GII.4 noroviruses (NoVs) are a single genotype that is responsible for over 50% of NoV gastroenteritis epidemics worldwide. However, GII.4 NoVs have been found to undergo antigenic drifts, likely selected by host herd immunity, which raises an issue for vaccine strategies against NoVs. We previously characterized GII.4 NoV antigenic variations and found significant levels of antigenic relatedness among...

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Antigens, Viral
Blood Group Antigens
Caliciviridae Infections
Conserved Sequence
Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gastroenteritis

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PMID: 25915764
DOI: 10.1371/journal.pone.0124945
PMCID: PMC4411064

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