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Article

Norovirus GII.4 Strain Antigenic Variation

28 Oct 2010

Abstract excerpt

Noroviruses are the principal cause of epidemic gastroenteritis worldwide. Multiple reports have concluded that the major capsid proteins of GII.4 strains, which cause 80% of norovirus infections worldwide, are evolving rapidly, resulting in new epidemic strains. Surrogate neutralization assays using sera from outbreaks and from immunized mice suggest that, as with influenza virus, antigenic variation maintains...

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PMID: 20980508
DOI: 10.1128/jvi.01364-10

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