Article

Harnessing <i>EGLN1</i> Gene Editing to Amplify HIF-1α and Enhance Human Angiogenic Response

2023-05-30

Abstract excerpt

<h4>ABSTRACT</h4> Therapeutic angiogenesis has been the focus of hundreds of clinical trials but approval for human treatment remains elusive. Current strategies often rely on the upregulation of a single proangiogenic factor, which fails to recapitulate the complex response needed in hypoxic tissues. Hypoxic oxygen tensions dramatically decrease the activity of hypoxia inducible factor prolyl hydroxylase 2 (PHD2...

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Literature Corpus work: f524435c-eae7-5936-8f26-163b208a7cb6
DOI: 10.1101/2023.05.29.542734

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