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Article

Ablation of cDC2 development by triple mutations within the Zeb2 enhancer.

Nature - 1 Jul 2022

Liu Tian-Tian, Kim Sunkyung, Desai Pritesh, Kim Do-Hyun, Huang Xiao, Ferris Stephen T, Wu Renee, Ou Feiya, Egawa Takeshi, Van Dyken Steven J, Diamond Michael S, Johnson Peter F, Kubo Masato, Murphy Theresa L, Murphy Kenneth M

Abstract excerpt

The divergence of the common dendritic cell progenitor1-3 (CDP) into the conventional type 1 and type 2 dendritic cell (cDC1 and cDC2, respectively) lineages4,5 is poorly understood. Some transcription factors act in the commitment of already specified progenitors-such as BATF3, which stabilizes Irf8 autoactivation at the +32 kb Irf8 enhancer4,6-but the mechanisms controlling the initial divergence of CDPs remain...

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Share to Basic-Leucine Zipper Transcription Factors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Enhancer Elements, Genetic

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Identifiers

PMID: 35732734
DOI: 10.1038/s41586-022-04866-z
PMCID: PMC10358283

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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