An Essential Developmental Checkpoint for Production of the T Cell Lineage

Abstract excerpt

One Two T T cells develop in the thymus, where they proceed through several developmental stages, losing alternative lineage potential as they progress. The molecular regulation of this developmental process, however, is not fully understood (see the Perspective by Di Santo ). P. Li et al. (p. 85 , published online 10 June), L. Li et al. (p. 89 ), and Ikawa et al. (p. 93 ) now identify expression of the zinc...

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