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Article

Integrating chromatin accessibility states in the design of targeted sequencing panels for liquid biopsy.

Scientific reports - 21 Jun 2022

Taklifi Pegah, Palizban Fahimeh, Mehrmohamadi Mahya

Abstract excerpt

Dying tumor cells shed DNA fragments into the circulation that are known as circulating tumor DNA (ctDNA). Liquid biopsy tests aim to detect cancer using known markers, including genetic alterations and epigenetic profiles of ctDNA. Despite various advantages, the major limitation remains the low fraction of tumor-originating DNA fragments in a high background of normal blood-cell originating fragments in the...

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Identifiers

PMID: 35729208
DOI: 10.1038/s41598-022-14675-z
PMCID: PMC9213477

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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