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Article

Liquid biopsies reveal dual compartments of cancer risk from tumor and host-derived mutations.

Bioinformatics (Oxford, England) - 1 Aug 2026

Malighetti Federica, Civettini Ivan, Aroldi Andrea, Villa Alberto Maria, Villa Matteo, Sala Luca, Cordani Nicoletta, Cadamuro Massimiliano, Cortinovis Diego, Piazza Rocco, Mologni Luca, Ramazzotti Daniele

Abstract excerpt

MOTIVATION: Circulating tumor DNA (ctDNA) and clonal hematopoiesis of indeterminate potential (CHIP) are two biologically distinct sources of somatic mutations detectable in blood. While ctDNA captures tumor-intrinsic alterations, CHIP arises from age-related hematopoietic clones and is often considered background noise. Here, we conduct a large-scale, tumor-type-resolved analysis of over 9000 patients with CHIP...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 42635246
DOI: 10.1093/bioinformatics/btag491
PMCID: PMC13501295

Genes

TP53
ASXL1
ATM
CHEK2
EGFR
KRAS
PPM1D
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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