Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication.

doi:10.1128/JVI.01543-07

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Article

Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication.

Journal of virology - 1 Nov 2007

Schneidewind Arne, Brockman Mark A, Yang Ruifeng, Adam Rahma I, Li Bin, Le Gall Sylvie, Rinaldo Charles R, Craggs Sharon L, Allgaier Rachel L, Power Karen A, Kuntzen Thomas, Tung Chang-Shung, LaBute Montiago X, Mueller Sandra M, Harrer Thomas, McMichael Andrew J, Goulder Philip J R, Aiken Christopher, Brander Christian, Kelleher Anthony D, Allen Todd M

Abstract excerpt

Human leukocyte antigen (HLA)-B27-positive subjects are uncommon in their ability to control infection with human immunodeficiency virus type 1 (HIV-1). However, late viral escape from a narrowly directed immunodominant Gag-specific CD8(+) T-lymphocyte (CTL) response has been linked to AIDS progression in these individuals. Identifying the mechanism of the immune-mediated control may provide critical insights...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17804494
DOI: 10.1128/JVI.01543-07
PMCID: PMC2169010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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