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Article

High-Throughput Variant Detection Using a Color-Mixing Strategy.

The Journal of molecular diagnostics : JMD - 1 Aug 2022

Xie Nina G, Zhang Kerou, Song Ping, Li Renqiang, Luo Junfeng, Zhang David Y

Abstract excerpt

Many diseases are related to multiple genetic alterations within a single gene. Probing for highly multiple (>10) variants in a single quantitative PCR tube is impossible because of a limited number of fluorescence channels and the limited ability to test one variant per channel, increasing the need for tubes. Herein, a novel color-mixing strategy was experimentally validated that uses fluorescence combinations...

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Identifiers

PMID: 35718091
DOI: 10.1016/j.jmoldx.2022.04.015
PMCID: PMC9379672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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