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Article

G-quadruplex-generating polymerase chain reaction for visual colorimetric detection of amplicons.

Analytical biochemistry - 15 Jan 2014

Bhadra Sanchita, Codrea Vlad, Ellington Andrew D

Abstract excerpt

We have developed a self-reporting polymerase chain reaction (PCR) system for visual colorimetric gene detection and distinction of single nucleotide polymorphisms (SNPs). Amplification is performed using target-specific primers modified with a 5'-end tail that is complementary to a G-quadruplex deoxyribozyme-forming sequence. At end-point, G-quadruplexes are forced to fold from PCR-generated duplex DNA and then...

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Identifiers

PMID: 24135653
DOI: 10.1016/j.ab.2013.10.010
PMCID: PMC3893031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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