Detection of Isoniazid-, Fluoroquinolone-, Amikacin-, and Kanamycin-Resistant Tuberculosis in an Automated, Multiplexed 10-Color Assay Suitable for Point-of-Care Use.

doi:10.1128/JCM.01771-16

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Article

Detection of Isoniazid-, Fluoroquinolone-, Amikacin-, and Kanamycin-Resistant Tuberculosis in an Automated, Multiplexed 10-Color Assay Suitable for Point-of-Care Use.

Journal of clinical microbiology - 1 Jan 2017

Chakravorty Soumitesh, Roh Sandy S, Glass Jennifer, Smith Laura E, Simmons Ann Marie, Lund Kevin, Lokhov Sergey, Liu Xin, Xu Peng, Zhang Guolong, Via Laura E, Shen Qingyu, Ruan Xianglin, Yuan Xing, Zhu Hong Zhu, Viazovkina Ekaterina, Shenai Shubhada, Rowneki Mazhgan, Lee Jong Seok, Barry Clifton E, Gao Qian, Persing David, Kwiatkawoski Robert, Jones Martin, Gall Alexander, Alland David

Abstract excerpt

Extensively drug-resistant (XDR) tuberculosis (TB) cannot be easily or quickly diagnosed. We developed a rapid, automated assay for the detection of XDR-TB plus resistance to the drug isoniazid (INH) for point-of-care use. Using a simple filter-based cartridge with an integrated sample processing function, the assay identified a wide selection of wild-type and mutant sequences associated with XDR-TB directly from...

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Identifiers

PMID: 27807153
DOI: 10.1128/JCM.01771-16
PMCID: PMC5228229

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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