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Article

DNA Methylation as a Potential Mediator of Environmental Risks in the Development of Childhood Acute Lymphoblastic Leukemia

1 Apr 2016

Abstract excerpt

5-year survival rate for childhood acute lymphoblastic leukemia (ALL) has risen to approximately 90%, yet the causal disease pathway is still poorly understood. Evidence suggests multiple 'hits' are required for disease progression; an initial genetic abnormality followed by additional secondary 'hits'. It is plausible that environmental influences may trigger these secondary hits, and with the peak incidence of...

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PMID: 27035209
DOI: 10.2217/epi-2015-0011

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