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Article

Filaggrin loss-of-function mutations are associated with persistence of egg and milk allergy.

The Journal of allergy and clinical immunology - 1 Nov 2022

Kalb Birgit, Marenholz Ingo, Jeanrenaud Alexander C S N, Meixner Lara, Arnau-Soler Aleix, Rosillo-Salazar Oscar D, Ghauri Ahla, Cibin Penelope, Blümchen Katharina, Schlags Rupert, Hansen Gesine, Seidenberg Jürgen, Keil Thomas, Lau Susanne, Niggemann Bodo, Beyer Kirsten, Lee Young-Ae

Abstract excerpt

BACKGROUND: A genetic defect in the epidermal barrier protein filaggrin (FLG) plays a major role in the etiology of eczema and associated allergic airways diseases. However, it is still controversial to what extend loss-of-function (LOF) mutations in FLG contribute to the development and persistence of food allergies. OBJECTIVES: This study tested association of FLG LOF mutations with allergic reactions to...

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Identifiers

PMID: 35714843
DOI: 10.1016/j.jaci.2022.05.018

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