Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Filaggrin loss-of-function mutations are associated with food allergy in childhood and adolescence.

The Journal of allergy and clinical immunology - 1 Oct 2014

Venkataraman Devasmitha, Soto-Ramírez Nelís, Kurukulaaratchy Ramesh J, Holloway John W, Karmaus Wilfried, Ewart Susan L, Arshad S Hasan, Erlewyn-Lajeunesse Mich

Abstract excerpt

BACKGROUND: Filaggrin is an epidermal protein that has a role in skin barrier function. Filaggrin loss-of-function (FLG-LOF) mutations are a significant risk factor for eczema and atopy, but their association with food allergy (FA) is less clear. OBJECTIVE: We explored the longitudinal relationship between 3 common FLG-LOF mutations and FA using the Isle of Wight birth cohort. METHODS: FA diagnosis was based on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allergens
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Filaggrin Proteins

Share to Follow-Up Studies

Share to Food Hypersensitivity

Share to Intermediate Filament Proteins

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 25174864
DOI: 10.1016/j.jaci.2014.07.033
PMCID: PMC4186905

Genes

FLG
FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Filaggrin loss-of-function mutations are associated with food allergy in childhood and adolescence.PMID 25174864Read ↗

Interplay of filaggrin loss-of-function variants, allergic sensitization, and eczema in a longitudinal study covering infancy to 18 years of age.Semantic proximity Read ↗

Filaggrin mutations increase allergic airway disease in childhood and adolescence through interactions with eczema and aeroallergen sensitization.Semantic proximity Read ↗

Association between loss-of-function mutations in the filaggrin gene and self-reported food allergy and alcohol sensitivity.Semantic proximity Read ↗

Filaggrin loss-of-function mutations are associated with persistence of egg and milk allergy.Semantic proximity Read ↗

Filaggrin loss-of-function variants are associated with atopic dermatitis phenotypes in a diverse, early-life prospective cohort.Semantic proximity Read ↗

An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthma.Semantic proximity Read ↗

Rare occurrence of common filaggrin mutations in Turkish children with food allergy and atopic dermatitisSemantic proximity Read ↗

Associations between child filaggrin mutations and maternal diet with the development of allergic diseases in children.Semantic proximity Read ↗

Skin barrier-related genes in childhood atopic dermatitis, asthma, and allergy: A systematic review and meta-analysis.Semantic proximity Read ↗

Loss-of-function variants of the filaggrin gene are associated with clinical reactivity to foods.Semantic proximity Read ↗

Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy.Semantic proximity Read ↗

Predictive value of food sensitization and filaggrin mutations in children with eczema.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.