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Article

Loss-of-function variants of the filaggrin gene are associated with clinical reactivity to foods.

Allergy - 1 Apr 2015

van Ginkel C D, Flokstra-de Blok B M J, Kollen B J, Kukler J, Koppelman G H, Dubois A E J

Abstract excerpt

The aim of this study was to assess the genetic association of Filaggrin loss-of-function (FLG LOF) genetic variants with food allergy, and to investigate the added value of this test in diagnosing food allergy. Clinical reactivity to foods was diagnosed by the gold standard, the double-blind, placebo-controlled food challenge. Of 155 children, 33 (21.3%) children had at least one FLG LOF variant, and of these,...

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Source

Identifiers

PMID: 25620092
DOI: 10.1111/all.12569

Genes

FLG

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