Article
Peanut allergy: effect of environmental peanut exposure in children with filaggrin loss-of-function mutations.
The Journal of allergy and clinical immunology - 1 Oct 2014
Brough Helen A, Simpson Angela, Makinson Kerry, Hankinson Jenny, Brown Sara, Douiri Abdel, Belgrave Danielle C M, Penagos Martin, Stephens Alick C, McLean W H Irwin, Turcanu Victor, Nicolaou Nicolaos, Custovic Adnan, Lack Gideon
Abstract excerpt
BACKGROUND: Filaggrin (FLG) loss-of-function mutations lead to an impaired skin barrier associated with peanut allergy. Household peanut consumption is associated with peanut allergy, and peanut allergen in household dust correlates with household peanut consumption. OBJECTIVE: We sought to determine whether environmental peanut exposure increases the odds of peanut allergy and whether FLG mutations modulate...
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