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Article

Exome sequencing reveals rare loss-of-function mutations in FLG and immune genes in patients with multiple food allergies.

The Journal of allergy and clinical immunology - 1 May 2026

Khanshour Anas M, Haddad Cynthia, Meregini Steve, Zamudio Mellisa, Arneson Amy, Parrish Christopher, Bird J Andrew, SoRelle Jeffrey A

Abstract excerpt

BACKGROUND: Studies of twins, parents, and families have demonstrated a strong heritable role in allergy and food allergy in particular (60%-80%). However, genetic loci identified in previous genome-wide association studies focused on common variants, have not withstood validation, are not located inside protein coding exons, do not explain familial allergy, or have a low effect size. OBJECTIVE: We sought to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41571042
DOI: 10.1016/j.jaci.2026.01.001

Genes

FLG
IFIH1
SMAD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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