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Article

A fundamental relationship between TCR diversity, repertoire size and systemic clonal expansion: insights from 30,000 TCRβ repertoires.

Frontiers in immunology - 1 Jan 2025

Zahid H Jabran, May Damon, Robins Harlan, Greissl Julia

Abstract excerpt

Introduction: T cell receptor (TCR) diversity is essential for immune defense, yet the mechanisms underlying its decline with age and its variation among individuals remain poorly understood. These patterns are typically attributed to passive processes such as thymic atrophy and cumulative immune exposures. However, this view does not account for the systematic and highly structured variation in TCR diversity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41583486
DOI: 10.3389/fimmu.2025.1707727
PMCID: PMC12823994

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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