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Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19

9 Aug 2022

Abstract excerpt

Whereas pathogen-specific T and B cells are a primary focus of interest during infectious disease, we have used COVID-19 to ask whether their emergence comes at a cost of broader B cell and T cell repertoire disruption. We applied a genomic DNA-based approach to concurrently study the immunoglobulin-heavy (IGH) and T cell receptor (TCR) β and δ chain loci of 95 individuals. Our approach detected anticipated...

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Share to Immune Cell Function and Interaction
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PMID: 35943978
DOI: 10.1073/pnas.2201541119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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