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Article

Dystrophin missense mutations alter focal adhesion tension and mechanotransduction.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jun 2022

Ramirez Maria Paz, Anderson Michael J M, Kelly Marcus D, Sundby Lauren J, Hagerty Anthony R, Wenthe Sophia J, Odde David J, Ervasti James M, Gordon Wendy R

Abstract excerpt

Dystrophin is an essential muscle protein that contributes to cell membrane stability by mechanically linking the actin cytoskeleton to the extracellular matrix via an adhesion complex called the dystrophin-glycoprotein complex. The absence or impaired function of dystrophin causes muscular dystrophy. Focal adhesions (FAs) are also mechanosensitive adhesion complexes that connect the cytoskeleton to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Focal Adhesions

Share to Mechanotransduction, Cellular

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Share to Muscle, Skeletal

Share to Muscular Dystrophy, Duchenne

Share to Mutation, Missense

Source

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Identifiers

PMID: 35700360
DOI: 10.1073/pnas.2205536119
PMCID: PMC9231619

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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