Article
Cellular microenvironments reveal defective mechanosensing responses and elevated YAP signaling in LMNA-mutated muscle precursors.
Journal of cell science - 1 Jul 2014
Bertrand Anne T, Ziaei Simindokht, Ehret Camille, Duchemin Hélène, Mamchaoui Kamel, Bigot Anne, Mayer Michèle, Quijano-Roy Susana, Desguerre Isabelle, Lainé Jeanne, Ben Yaou Rabah, Bonne Gisèle, Coirault Catherine
Abstract excerpt
The mechanisms underlying the cell response to mechanical forces are crucial for muscle development and functionality. We aim to determine whether mutations of the LMNA gene (which encodes lamin A/C) causing congenital muscular dystrophy impair the ability of muscle precursors to sense tissue stiffness and to respond to mechanical challenge. We found that LMNA-mutated myoblasts embedded in soft matrix did not...
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