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Article

RshA mutations contributing to tigecycline resistance in Mycobacteroides abscessus.

Journal of medical microbiology - 1 Jun 2022

Aw Kar Men, Ng Hien Fuh, Lee Col Lin, Zin Thaw, Ngeow Yun Fong

Abstract excerpt

Tigecycline is an important rescue antibiotic for many bacterial infections. In Mycobacteroides abscessus, tigecycline resistance has been associated with dysregulated stress response caused by aberrations in the interaction of the SigH and RshA factors. In this study, two tigecycline-resistant mutants of M. abscessus (CL5A and CL6A) with mutations in the rshA gene were studied using gene complementation, RT-qPCR...

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Source

Identifiers

PMID: 35700112
DOI: 10.1099/jmm.0.001547

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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