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Article

Genome-wide causal mediation analysis identifies genetic loci associated with uterine fibroids mediated by age at menarche.

Human reproduction (Oxford, England) - 25 Aug 2022

Tai An-Shun, Lin Ro-Ting, Lin Yi-Chun, Wang Chung-Hsing, Lin Sheng-Hsuan, Imoto Seiya

Abstract excerpt

STUDY QUESTION: Could the direct contribution of genetic variants to the pathophysiology of uterine fibroids and the contribution mediated by age at menarche be different? SUMMARY ANSWER: Age at menarche plays a mediation role in the genetic influence on uterine fibroids, and four causal genetic mechanisms underlying the age at menarche-mediated effects of common genetic loci on uterine fibroid development were...

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Identifiers

PMID: 35689443
DOI: 10.1093/humrep/deac136
PMCID: PMC10467635

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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