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Generation of α-1,3-galactosyltransferase knocked-out transgenic cloned pigs with knocked-in five human genes

23 Aug 2016

Abstract excerpt

Recent progress in genetic manipulation of pigs designated for xenotransplantation ha6s shown considerable promise on xenograft survival in primates. However, genetic modification of multiple genes in donor pigs by knock-out and knock-in technologies, aiming to enhance immunological tolerance against transplanted organs in the recipients, has not been evaluated for health issues of donor pigs. We produced...

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PMID: 27554374
DOI: 10.1007/s11248-016-9979-8

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