Article
Fragile X mice have robust mGluR5-dependent alterations of social behaviour in the Automated Tube Test.
Neurobiology of disease - 1 Mar 2015
de Esch C E F, van den Berg W E, Buijsen R A M, Jaafar I A, Nieuwenhuizen-Bakker I M, Gasparini F, Kushner S A, Willemsen R
Abstract excerpt
Fragile X syndrome is the most common monogenetic form of intellectual disability and autism. Although the Fmr1 knockout mouse model recapitulates many aspects of the human FXS condition, the establishment of robust social behavioural phenotypes suitable for drug screening has been difficult. Here, we describe a novel social behavioural paradigm, the Automated Tube Test (ATT), for which Fmr1 knockout mice...
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