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The potential of circulating tumor DNA methylation analysis for the early detection and management of ovarian cancer

1 Dec 2017

Abstract excerpt

BACKGROUND: Despite a myriad of attempts in the last three decades to diagnose ovarian cancer (OC) earlier, this clinical aim still remains a significant challenge. Aberrant methylation patterns of linked CpGs analyzed in DNA fragments shed by cancers into the bloodstream (i.e. cell-free DNA) can provide highly specific signals indicating cancer presence. METHODS: We analyzed 699 cancerous and non-cancerous...

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PMID: 29268796
DOI: 10.1186/s13073-017-0500-7

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