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Early Detection of Ovarian Cancer Using Cell-Free DNA Fragmentomes and Protein Biomarkers

30 Sept 2024

Abstract excerpt

Abstract Ovarian cancer is a leading cause of death for women worldwide, in part due to ineffective screening methods. In this study, we used whole-genome cell-free DNA (cfDNA) fragmentome and protein biomarker [cancer antigen 125 (CA-125) and human epididymis protein 4 (HE4)] analyses to evaluate 591 women with ovarian cancer, with benign adnexal masses, or without ovarian lesions. Using a machine learning model...

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PMID: 39345137
DOI: 10.1158/2159-8290.cd-24-0393

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