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Article

Magnetic resonance metabolic imaging of glioma.

Science translational medicine - 11 Jan 2012

Metellus Philippe, Figarella-Branger Dominique

Abstract excerpt

2-Hydroxyglutarate (2-HG) is a potential oncometabolite involved in gliomagenesis that has been identified as an aberrant product of isocitrate dehydrogenase (IDH)-mutated glial tumors. Recent genomics studies have shown that heterozygous mutation of IDH genes 1 and 2, present in up to 86% of grade II gliomas, is associated with a favorable outcome. Two reports in this issue describe both ex vivo and in vivo...

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Identifiers

PMID: 22238331
DOI: 10.1126/scitranslmed.3003591

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Magnetic resonance metabolic imaging of glioma.PMID 22238331Read ↗

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Imaging biomarkers for detecting IDH mutations and monitoring response to novel targeted therapies: Current insights and future perspectives.Semantic proximity Read ↗

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Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma.Semantic proximity Read ↗

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2-Hydroxyglutarate as an MR spectroscopic predictor of an IDH mutation in gliomas.Semantic proximity Read ↗

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