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Article

Age-Related Intimal Stiffening Enhances Endothelial Permeability and Leukocyte Transmigration

7 Dec 2011

Abstract excerpt

Age is the most significant risk factor for atherosclerosis; however, the link between age and atherosclerosis is poorly understood. During both aging and atherosclerosis progression, the blood vessel wall stiffens owing to alterations in the extracellular matrix. Using in vitro and ex vivo models of vessel wall stiffness and aging, we show that stiffening of extracellular matrix within the intima promotes...

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PMID: 22158860
DOI: 10.1126/scitranslmed.3002761

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