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Article

Consequences of the Hsp110DE9 mutation in tumorigenesis and the 5-fluorouracil-based chemotherapy response in Msh2-deficient mice.

Cellular and molecular life sciences : CMLS - 1 Jun 2022

Noel Kathleen, Bokhari A 'dem, Bertrand Romane, Renaud Florence, Bourgoin Pierre, Cohen Romain, Svrcek Magali, Joly Anne-Christine, Duval Alex, Collura Ada

Abstract excerpt

Heat shock proteins (HSPs) play oncogenic roles in human tumours. We reported a somatic inactivating mutation of HSP110 (HSP110DE9) in mismatch repair-deficient (dMMR) cancers displaying microsatellite instability (MSI) but did not assess its impact. We evaluated the impact of the Hsp110DE9 mutation on tumour development and the chemotherapy response in a dMMR knock-in mouse model (Hsp110DE9KIMsh2KO mice). The...

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Identifiers

PMID: 35648235
DOI: 10.1007/s00018-022-04293-3
PMCID: PMC11072706

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