Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity.

Abstract excerpt

The vast majority of human tumors with p53 mutations undergo loss of the remaining wildtype p53 allele (loss-of-heterozygosity, p53LOH). p53LOH has watershed significance in promoting tumor progression. However, driving forces for p53LOH are poorly understood. Here we identify the repressive WTp53-HSF1 axis as one driver of p53LOH. We find that the WTp53 allele in AOM/DSS chemically-induced colorectal tumors...

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• Cell Cycle Checkpoints
• Colorectal Neoplasms
• Cyclin-Dependent Kinase Inhibitor p21
• HCT116 Cells
• Heat Shock Transcription Factors