Expression of a mutant HSP110 sensitizes colorectal cancer cells to chemotherapy and improves disease prognosis.

doi:10.1038/nm.2457

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Article

Expression of a mutant HSP110 sensitizes colorectal cancer cells to chemotherapy and improves disease prognosis.

Nature medicine - 25 Sept 2011

Dorard Coralie, de Thonel Aurélie, Collura Ada, Marisa Laetitia, Svrcek Magali, Lagrange Anaïs, Jego Gaetan, Wanherdrick Kristell, Joly Anne Laure, Buhard Olivier, Gobbo Jessica, Penard-Lacronique Virginie, Zouali Habib, Tubacher Emmanuel, Kirzin Sylvain, Selves Janick, Milano Gérard, Etienne-Grimaldi Marie-Christine, Bengrine-Lefèvre Leila, Louvet Christophe, Tournigand Christophe, Lefèvre Jérémie H, Parc Yann, Tiret Emmanuel, Fléjou Jean-François, Gaub Marie-Pierre, Garrido Carmen, Duval Alex

Abstract excerpt

Heat shock proteins (HSPs) are necessary for cancer cell survival. We identified a mutant of HSP110 (HSP110ΔE9) in colorectal cancer showing microsatellite instability (MSI CRC), generated from an aberrantly spliced mRNA and lacking the HSP110 substrate-binding domain. This mutant was expressed at variable levels in almost all MSI CRC cell lines and primary tumors tested. HSP110ΔE9 impaired both the normal...

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PMID: 21946539
DOI: 10.1038/nm.2457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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