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Article

Expression status of wild-type HSP110 correlates with HSP110 T17 deletion size and patient prognosis in microsatellite-unstable colorectal cancer.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2014

Kim Jung Ho, Kim Kyung-Ju, Rhee Ye-Young, Oh Sohee, Cho Nam-Yun, Lee Hye Seung, Kang Gyeong Hoon

Abstract excerpt

It has been recently suggested that the expression levels of mutant HSP110 could be a prognostic marker in colorectal cancer with a high level of microsatellite instability (MSI-H). The aim of our study was to validate the prognostic significance of HSP110 mutation using immunohistochemistry and DNA testing in MSI-H colorectal cancer. Wild-type HSP110 (HSP110wt)-specific immunohistochemistry was performed in 168...

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Colorectal Neoplasms
Disease-Free Survival
Gene Deletion
Immunohistochemistry
Kaplan-Meier Estimate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microsatellite Instability

Proportional Hazards Models

Reverse Transcriptase Polymerase Chain Reaction

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PMID: 24030751
DOI: 10.1038/modpathol.2013.160

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