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Article

MSH2 missense mutations alter cisplatin cytotoxicity and promote cisplatin-induced genome instability.

Nucleic acids research - 1 Jan 2005

Clodfelter Jill E, B Gentry Michael, Drotschmann Karin

Abstract excerpt

Defects in the mismatch repair protein MSH2 cause tolerance to DNA damage. We report how cancer-derived and polymorphic MSH2 missense mutations affect cisplatin cytotoxicity. The chemotolerance phenotype was compared with the mutator phenotype in a yeast model system. MSH2 missense mutations display a strikingly different effect on cell death and genome instability. A mutator phenotype does not predict...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15947132
DOI: 10.1093/nar/gki646
PMCID: PMC1148170

Genes

MSH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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