Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The E705K mutation in hPMS2 exerts recessive, not dominant, effects on mismatch repair.

Cancer letters - 8 May 2007

Deschênes Suzanne M, Tomer Guy, Nguyen Megan, Erdeniz Naz, Juba Nicole C, Sepúlveda Natalia, Pisani Jenna E, Liskay R Michael

Abstract excerpt

The hPMS2 mutation E705K is associated with Turcot syndrome. To elucidate the pathogenesis of hPMS2-E705K, we modeled this mutation in yeast and characterized its expression and effects on mutation avoidance in mammalian cells. We found that while hPMS2-E705K (pms1-E738K in yeast) did not signifi...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to DNA Mismatch Repair
Share to DNA Repair Enzymes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Dominant

Share to Genes, Recessive

Share to Mismatch Repair Endonuclease PMS2

Share to Neoplastic Syndromes, Hereditary

Share to Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 17029773
DOI: 10.1016/j.canlet.2006.08.008
PMCID: PMC2366906

Genes

MLH1
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17029773-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The E705K mutation in hPMS2 exerts recessive, not dominant, effects on mismatch repair.PMID 17029773Read ↗

Identification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function.Semantic proximity Read ↗

MSH2 missense mutations alter cisplatin cytotoxicity and promote cisplatin-induced genome instability.Semantic proximity Read ↗

Lynch syndrome-associated mutations in MSH2 alter DNA repair and checkpoint response functions in vivo.Semantic proximity Read ↗

Human MutL homolog (MLH1) function in DNA mismatch repair: a prospective screen for missense mutations in the ATPase domainSemantic proximity Read ↗

Dominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway.Semantic proximity Read ↗

Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse.Semantic proximity Read ↗

Rad5 and Its Human Homologs, HLTF and SHPRH, Are Novel Interactors of Mismatch RepairSemantic proximity Read ↗

exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repair.Semantic proximity Read ↗

MSH2 is essential for the preservation of genome integrity and prevents homeologous recombination in the moss Physcomitrella patens.Semantic proximity Read ↗

Mutator phenotypes of yeast strains heterozygous for mutations in the MSH2 gene.Semantic proximity Read ↗

Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations.Semantic proximity Read ↗

Functional analysis of human mismatch repair gene mutations identifies weak alleles and polymorphisms capable of polygenic interactions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.