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Mammalian Display Platform for the Maturation of Bispecific TCR-Based Molecules

10 May 2022

Abstract excerpt

Bispecific T cell receptor (TCR)-based molecules capable of redirecting and activating T cells towards tumor cells represent a novel and promising class of biotherapeutics for the treatment of cancer. Usage of TCRs allows for targeting of intracellularly expressed and highly selective cancer antigens, but also requires a complex maturation process to increase the naturally low affinity and stability of TCRs. Even...

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PMID: 35645207
DOI: 10.3390/antib11020034

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