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A library of cancer testis specific T cell receptors for T cell receptor gene therapy

2 Dec 2022

Abstract excerpt

To increase the number of cancer patients that can be treated with T cell receptor (TCR) gene therapy, we aimed to identify a set of high-affinity cancer-specific TCRs targeting different melanoma-associated antigens (MAGEs). In this study, peptides derived from MAGE genes with tumor-specific expression pattern were identified by human leukocyte antigen (HLA) peptidomics. Next, peptide-HLA tetramers were...

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PMID: 36589698
DOI: 10.1016/j.omto.2022.11.007

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